I think that re-assembly out of the frame is far better. There is far less caution and finesse needed when dismantling, but rebuilding successfully is easier to achieve without frame tubes, cables, and wires getting in the way, plus of course you will be constantly working on either side of the engine, which is made easier if you can just turn the engine round in front of you on a bench. (Whilst comfortably seated on your stool!!!). The only down side being that you may have to enlist the help of a friend to lower the frame over the finished item.