My '69 sandcast is at 116,000 now (94,000 of them are mine). Cam chain, primary chain, and tensioners were changed at 32,000 when the head gasket needed doing. Every other major part is factory still (pistons, rings, valves, crank shells, clutch plates, etc. It is not the quietest CB750 motor on the planet, but does not burn oil still (not like my F2!) and goes great. Even the rear wheel sprocket is original still, with negligible wear showing (I do fit a new drive chain every time the rear tyre is changed though, and of course it has never seen UK winter weather).
There is an F1 in the Uk with over 150,000 miles up now; no idea what work if any has been necessary.
I also have a 400/4 I used daily throughout the 80's which reached 108,000, again without any major work. Still ran good, but due to winter use evrthing that could rot away did, so I stopped using it and restored that one.
Chris R.